The Roles of Circular RNAs in Ischemic Stroke through Modulating Neuroinflammation

Xin Gu; Lingfei Li; Biao Chen; Yuyao Zhang; Yongji Zhou; Keqin Liu; Wenqin Xia; Xiaoqin Li; Zheng Zhang; Huanqing Shi; Jinyu Huang; Beibei Gao; Lin Jiang; Anwen Shao; Congguo Yin

doi:10.31083/j.jin2304087

Journal of Integrative Neuroscience (Apr 2024)

The Roles of Circular RNAs in Ischemic Stroke through Modulating Neuroinflammation

Xin Gu,
Lingfei Li,
Biao Chen,
Yuyao Zhang,
Yongji Zhou,
Keqin Liu,
Wenqin Xia,
Xiaoqin Li,
Zheng Zhang,
Huanqing Shi,
Jinyu Huang,
Beibei Gao,
Lin Jiang,
Anwen Shao,
Congguo Yin

Affiliations

Xin Gu: The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China
Lingfei Li: Department of Neurology, Hangzhou First People’s Hospital, 310006 Hangzhou, Zhejiang, China
Biao Chen: The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China
Yuyao Zhang: The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China
Yongji Zhou: Department of Neurology, Hangzhou First People’s Hospital, 310006 Hangzhou, Zhejiang, China
Keqin Liu: Department of Neurology, Hangzhou First People’s Hospital, 310006 Hangzhou, Zhejiang, China
Wenqin Xia: Department of Neurology, Hangzhou First People’s Hospital, 310006 Hangzhou, Zhejiang, China
Xiaoqin Li: The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China
Zheng Zhang: The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China
Huanqing Shi: The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China
Jinyu Huang: Department of Cardiology, Hangzhou First People’s Hospital, 310006 Hangzhou, Zhejiang, China
Beibei Gao: Department of Cardiology, Hangzhou First People’s Hospital, 310006 Hangzhou, Zhejiang, China
Lin Jiang: Department of Neurology, Hangzhou First People’s Hospital, 310006 Hangzhou, Zhejiang, China
Anwen Shao: Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, 310009 Hangzhou, Zhejiang, China
Congguo Yin: The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China

DOI: https://doi.org/10.31083/j.jin2304087
Journal volume & issue: Vol. 23, no. 4
p. 87

Abstract

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Ischemic stroke (IS) remains a serious threat to human health. Neuroinflammatory response is an important pathophysiological process after IS. Circular RNAs (circRNAs), a member of the non-coding RNA family, are highly expressed in the central nervous system and widely involved in regulating physiological and pathophysiological processes. This study reviews the current evidence on neuroinflammatory responses, the role of circRNAs in IS and their potential mechanisms in regulating inflammatory cells, and inflammatory factors affecting IS damage. This review lays a foundation for future clinical application of circRNAs as novel biomarkers and therapeutic targets.

Published in Journal of Integrative Neuroscience

ISSN: 0219-6352 (Print); 1757-448X (Online)
Publisher: IMR Press
Country of publisher: Singapore
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.imrpress.com/journal/JIN

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