Activation of STING Based on Its Structural Features

Behzad Hussain; Yufeng Xie; Uzma Jabeen; Defen Lu; Bo Yang; Bo Yang; Changxin Wu; Guijun Shang; Guijun Shang

doi:10.3389/fimmu.2022.808607

Frontiers in Immunology (Jul 2022)

Activation of STING Based on Its Structural Features

Behzad Hussain,
Yufeng Xie,
Uzma Jabeen,
Defen Lu,
Bo Yang,
Bo Yang,
Changxin Wu,
Guijun Shang,
Guijun Shang

Affiliations

Behzad Hussain: The Key Laboratory of Medical Molecular Cell Biology of Shanxi Province, The Institutes of Biomedical Sciences, Shanxi University, Taiyuan, China
Yufeng Xie: Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China
Uzma Jabeen: Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Defen Lu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Bo Yang: Shanxi Provincial Key Laboratory of Protein Structure Determination, Shanxi Academy of Advanced Research and Innovation, Taiyuan, China
Bo Yang: Shanxi Provincial Key Laboratory for Major Infectious Disease Response, Shanxi Academy of Advanced Research and Innovation, Taiyuan, China
Changxin Wu: The Key Laboratory of Medical Molecular Cell Biology of Shanxi Province, The Institutes of Biomedical Sciences, Shanxi University, Taiyuan, China
Guijun Shang: Shanxi Provincial Key Laboratory of Protein Structure Determination, Shanxi Academy of Advanced Research and Innovation, Taiyuan, China
Guijun Shang: Shanxi Provincial Key Laboratory for Major Infectious Disease Response, Shanxi Academy of Advanced Research and Innovation, Taiyuan, China

DOI: https://doi.org/10.3389/fimmu.2022.808607
Journal volume & issue: Vol. 13

Abstract

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The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers. Recently, tremendous progress has been made in the understanding of the STING activation mechanism from various aspects. In this review, the molecular mechanism of activation of STING protein based on its structural features is briefly discussed. The underlying molecular mechanism of STING activation will enable us to develop novel therapeutics to treat STING-associated diseases and understand how STING has evolved to eliminate infection and maintain immune homeostasis in innate immunity.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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