eJHaem
(May 2022)
The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease
Hirokazu Miki,
Shingen Nakamura,
Masahiro Oura,
Masafumi Nakamura,
Ryohei Sumitani,
Kimiko Sogabe,
Mamiko Takahashi,
Tomoko Maruhashi,
Takeshi Harada,
Shiro Fujii,
Hirofumi Hamano,
Masateru Kondo,
Naoto Okada,
Itsuro Endo,
Masahiro Abe
Affiliations
Hirokazu Miki
Division of Transfusion Medicine and Cell Therapy Tokushima University Hospital Tokushima Japan
Shingen Nakamura
Department of Community Medicine and Medical Science Tokushima University Graduate School of Biomedical Sciences Tokushima Japan
Masahiro Oura
Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Masafumi Nakamura
Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Ryohei Sumitani
Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Kimiko Sogabe
Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Mamiko Takahashi
Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Tomoko Maruhashi
Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Takeshi Harada
Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Shiro Fujii
Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Hirofumi Hamano
Clinical Research Center for Developmental Therapeutics Tokushima University Hospital Tokushima Japan
Masateru Kondo
Department of Pharmacy Tokushima University Hospital Tokushima Japan
Naoto Okada
Department of Pharmacy Tokushima University Hospital Tokushima Japan
Itsuro Endo
Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Masahiro Abe
Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
DOI
https://doi.org/10.1002/jha2.402
Journal volume & issue
Vol. 3,
no. 2
Abstract
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Abstract This study was undertaken to identify baseline conditions and triggering factors for skeletal‐related events (SRE) in multiple myeloma (MM) patients treated with denosumab. During the median follow‐up of 17 months, SRE occurred in 6 out of 52 newly diagnosed patients and in 5 out of 23 relapsed/refractory patients. Bone fractures occurred by falling down due to orthostatic hypotension and/or muscle weakness in three out of four cases with amyloid light‐chain (AL) amyloidosis. A loss of balance and falling down appear to be triggering factors for SRE, especially in frail MM patients with AL amyloidosis, indicating the importance of retaining physical functions to prevent SRE.
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