Фармакокинетика и Фармакодинамика (Nov 2023)

Сardioprotective agents with biaromatic structure. Part 6. Beta blockers

  • G. V. Mokrov

DOI
https://doi.org/10.37489/2587-7836-2023-3-3-11
Journal volume & issue
Vol. 0, no. 3
pp. 3 – 11

Abstract

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β-Blockers are one of the oldest classes of cardioprotectors used in the treatment of cardiovascular diseases. They reduce the heart rate, have a hypotensive effect, inhibit myocardial contractility and have antiarrhythmic properties. In the series of biaromatic compounds with a linear linker, there is a quite large group of β-blockers, which in addition to two aromatic nuclei contain a 1,2-dihydroxy-3-aminopropane fragment in the linker, that is the key for the presence of β-blocking activity. Among the compounds of this group are widely used drugs nebivolol and carvedilol, which are used in the treatment of chronic heart failure and arterial hypertension.

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