Impact of SARS-CoV-2 on the clinical outcomes and placental pathology of pregnant women and their infants: A systematic review
Irina Oltean,
Jason Tran,
Sarah Lawrence,
Brittany Ann Ruschkowski,
Na Zeng,
Cameron Bardwell,
Youssef Nasr,
Joseph de Nanassy,
Dina El Demellawy
Affiliations
Irina Oltean
Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, K1H 8L1, Canada
Jason Tran
Department of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5 Canada
Sarah Lawrence
Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, K1H 8L1, Canada; Department of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5 Canada; Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1, Canada
Brittany Ann Ruschkowski
Department of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5 Canada
Na Zeng
Department of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5 Canada
Cameron Bardwell
Department of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5 Canada
Youssef Nasr
Department of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5 Canada
Joseph de Nanassy
Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, K1H 8L1, Canada; Department of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5 Canada; Department of Pathology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1, Canada
Dina El Demellawy
Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, K1H 8L1, Canada; Department of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5 Canada; Department of Pathology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1, Canada; Corresponding author.
Pregnant women are susceptible to viral infections due to physiological changes such as cell-mediated immunity. No severe adverse pregnancy or neonatal outcomes have been consistently reported in 2019 novel coronavirus disease (COVID-19) positive pregnancy cases. There are controversies around the role of COVID-19 in pregnancy. A systematic review was conducted to examine clinical maternal and neonatal clinical outcomes. Studies were included if they reported SARS-CoV-2 infection among pregnant women and/or COVID-19 positive neonates as validated by positive antibody testing or viral testing using polymerase chain reaction. Case series, case reports, case-control studies, and comparative studies were included. Eight hundred and thirty-seven records were identified, resulting in 525 records for level I screening. Forty-one were included after full-text review. Results suggest elevated rates of intensive care unit (ICU) admission, gestational diabetes, preeclampsia, C-sections, pre-term birth, and C-reactive protein (CRP) in comparison to pregnant women without SARS-CoV-2. Careful monitoring of pregnancies with SARS-CoV-2 is recommended.
