Preliminary assessment of influence of calcium alginate beads on the dissolution of meloxicam

Abstract

The purpose of the study was to evaluate the preparation of alginate-based microparticles with meloxicam (MLX). A poorly soluble substance classified to BCS class II, it was chosen as a model substance. The ionotropic gelation was the process used for the formation of microparticles. The impact of the carrier on the dissolution of MLX from this formulation was also investigated. Study was realized in few steps: preparation of polymer particles containing suspended MLX in their structure; drying them in various conditions (room temperature, freeze drying); morphology characterization and then assessment of impact of polymer on dissolution of the model substance. Also, DDSolver software was used for checking the similarity of release profiles. Validated UV-Vis spectrophotometric method was used for MLX determination on different steps of work. As it showed, calcium alginate particles were successfully prepared with ionotropic gelation. The drying method of prepared particles has a substantial impact on the release profiles of meloxicam, and these formulations significantly improve the MLX release from this form of the delivery system.

Keywords

• calcium alginate
• dissolution profile
• ionotropic gelation
• drug delivery system
• polymeric particles