SUV39H1-driven NFATc1 methylation is essential for the c-Cbl-mediated degradation of NFATc1 in an osteoclast lineage

• Do-Won Jeong,
• Hye-Jin Kim,
• Jong-Wan Park,
• Seulbee Lee,
• Hyeryeon Jung,
• Eugene C. Yi,
• Nacksung Kim,
• Yang-Sook Chun

Affiliations

Do-Won Jeong

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Hye-Jin Kim

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Jong-Wan Park

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Seulbee Lee

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Hyeryeon Jung

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Or College of Pharmacy, Seoul National University, Seoul 03080, Republic of Korea

Eugene C. Yi

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Or College of Pharmacy, Seoul National University, Seoul 03080, Republic of Korea

Nacksung Kim

Department of Pharmacology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea

Yang-Sook Chun

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Corresponding author. Department of Biomedical Sciences Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.