Anti-bacterial screening and sequential synthesis of 1,2,3-triazoles ‎from alcohols and epoxides in water

Abstract

The triazole core is an important part of the therapeutically drugs such as antimicrobial, analgesic and anti-inflammatory agents. Therefore, a facile synthesis of a series of 1,2,3-triazoles has been introduced by the sequential azidation of alcohols or epoxides and then Cu (I)-catalyzed azide-alkyne cycloaddition (CuAAC) in water. The biological profiles of some of these five-membered heterocyclic scaffolds toward anti-bacterial activities were evaluated using Kirby-Bauer Disc Diffusion method. The biological obtained results were very interesting and revealed that most of the examined molecules are potent antibacterial agents when compared with standard drugs.

Keywords

• anti-bacterial
• 1
• 2
• 3-triazoles
• alkyl azides
• epoxides
• click reaction