Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine

Julia Dietler; Renate Gelfert; Jennifer Kaiser; Veniamin Borin; Christian Renzl; Sebastian Pilsl; Américo Tavares Ranzani; Andrés García de Fuentes; Tobias Gleichmann; Ralph P. Diensthuber; Michael Weyand; Günter Mayer; Igor Schapiro; Andreas Möglich

doi:10.1038/s41467-022-30252-4

Nature Communications (May 2022)

Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine

Julia Dietler,
Renate Gelfert,
Jennifer Kaiser,
Veniamin Borin,
Christian Renzl,
Sebastian Pilsl,
Américo Tavares Ranzani,
Andrés García de Fuentes,
Tobias Gleichmann,
Ralph P. Diensthuber,
Michael Weyand,
Günter Mayer,
Igor Schapiro,
Andreas Möglich

Affiliations

Julia Dietler: Department of Biochemistry, University of Bayreuth
Renate Gelfert: Department of Biochemistry, University of Bayreuth
Jennifer Kaiser: Department of Biochemistry, University of Bayreuth
Veniamin Borin: Institute of Chemistry, The Hebrew University of Jerusalem
Christian Renzl: Life and Medical Sciences (LIMES), University of Bonn
Sebastian Pilsl: Life and Medical Sciences (LIMES), University of Bonn
Américo Tavares Ranzani: Department of Biochemistry, University of Bayreuth
Andrés García de Fuentes: Department of Biochemistry, University of Bayreuth
Tobias Gleichmann: Biophysical Chemistry, Humboldt-University Berlin
Ralph P. Diensthuber: Biophysical Chemistry, Humboldt-University Berlin
Michael Weyand: Department of Biochemistry, University of Bayreuth
Günter Mayer: Life and Medical Sciences (LIMES), University of Bonn
Igor Schapiro: Institute of Chemistry, The Hebrew University of Jerusalem
Andreas Möglich: Department of Biochemistry, University of Bayreuth

DOI: https://doi.org/10.1038/s41467-022-30252-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Light-oxygen-voltage (LOV) photoreceptors perceive blue light to elicit spatio-temporally defined cellular responses, and their signalling process has been extensively characterized. Here the authors report that the light signal is still transduced in the absence of a conserved Gln residue, thought to be key.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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