Nature Communications (Oct 2023)
Spatial and temporal dynamics of West Nile virus between Africa and Europe
- Giulia Mencattelli,
- Marie Henriette Dior Ndione,
- Andrea Silverj,
- Moussa Moise Diagne,
- Valentina Curini,
- Liana Teodori,
- Marco Di Domenico,
- Rassoul Mbaye,
- Alessandra Leone,
- Maurilia Marcacci,
- Alioune Gaye,
- ElHadji Ndiaye,
- Diawo Diallo,
- Massimo Ancora,
- Barbara Secondini,
- Valeria Di Lollo,
- Iolanda Mangone,
- Andrea Bucciacchio,
- Andrea Polci,
- Giovanni Marini,
- Roberto Rosà,
- Nicola Segata,
- Gamou Fall,
- Cesare Cammà,
- Federica Monaco,
- Mawlouth Diallo,
- Omar Rota-Stabelli,
- Oumar Faye,
- Annapaola Rizzoli,
- Giovanni Savini
Affiliations
- Giulia Mencattelli
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Marie Henriette Dior Ndione
- Virology Department, Institut Pasteur de Dakar
- Andrea Silverj
- Centre Agriculture Food Environment, University of Trento
- Moussa Moise Diagne
- Virology Department, Institut Pasteur de Dakar
- Valentina Curini
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Liana Teodori
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Marco Di Domenico
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Rassoul Mbaye
- Virology Department, Institut Pasteur de Dakar
- Alessandra Leone
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Maurilia Marcacci
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Alioune Gaye
- Medical Zoology Department, Institut Pasteur de Dakar
- ElHadji Ndiaye
- Medical Zoology Department, Institut Pasteur de Dakar
- Diawo Diallo
- Medical Zoology Department, Institut Pasteur de Dakar
- Massimo Ancora
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Barbara Secondini
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Valeria Di Lollo
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Iolanda Mangone
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Andrea Bucciacchio
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Andrea Polci
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Giovanni Marini
- Research and Innovation Centre, Fondazione Edmund Mach
- Roberto Rosà
- Centre Agriculture Food Environment, University of Trento
- Nicola Segata
- Department CIBIO, University of Trento
- Gamou Fall
- Virology Department, Institut Pasteur de Dakar
- Cesare Cammà
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Federica Monaco
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- Mawlouth Diallo
- Medical Zoology Department, Institut Pasteur de Dakar
- Omar Rota-Stabelli
- Centre Agriculture Food Environment, University of Trento
- Oumar Faye
- Virology Department, Institut Pasteur de Dakar
- Annapaola Rizzoli
- Research and Innovation Centre, Fondazione Edmund Mach
- Giovanni Savini
- Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise
- DOI
- https://doi.org/10.1038/s41467-023-42185-7
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 11
Abstract
Abstract It is unclear whether West Nile virus (WNV) circulates between Africa and Europe, despite numerous studies supporting an African origin and high transmission in Europe. We integrated genomic data with geographic observations and phylogenetic and phylogeographic inferences to uncover the spatial and temporal viral dynamics of WNV between these two continents. We focused our analysis towards WNV lineages 1 (L1) and 2 (L2), the most spatially widespread and pathogenic WNV lineages. Our study shows a Northern-Western African origin of L1, with back-and-forth exchanges between West Africa and Southern-Western Europe; and a Southern African origin of L2, with one main introduction from South Africa to Europe, and no back introductions observed. We also noticed a potential overlap between L1 and L2 Eastern and Western phylogeography and two Afro-Palearctic bird migratory flyways. Future studies linking avian and mosquito species susceptibility, migratory connectivity patterns, and phylogeographic inference are suggested to elucidate the dynamics of emerging viruses.
