Haematologica (Jan 2010)

Thymosin β4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma

  • Jo Caers,
  • Dirk Hose,
  • Ine Kuipers,
  • Tomas Jan Bos,
  • Els Van Valckenborgh,
  • Eline Menu,
  • Elke De Bruyne,
  • Hartmut Goldschmidt,
  • Ben Van Camp,
  • Bernard Klein,
  • Karin Vanderkerken

DOI
https://doi.org/10.3324/haematol.2009.006411
Journal volume & issue
Vol. 95, no. 1

Abstract

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Thymosin β4 (Tβ4) is a polypeptide involved in cellular proliferation, differentiation, and migration, over-expressed in several tumor entities. We evaluated its expression and function in 298 newly diagnosed multiple myeloma patients and the murine 5TMM model. Mean Tβ4 expression was significantly lower in myeloma cells compared to normal plasma cells (P