Molecular Therapy: Nucleic Acids (Mar 2021)
Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma
- Yi Shi,
- Dan-Dan Zhang,
- Ji-Bin Liu,
- Xiao-Li Yang,
- Rui Xin,
- Cheng-You Jia,
- Hui-Min Wang,
- Gai-Xia Lu,
- Pei-Yao Wang,
- Yu Liu,
- Zi-Jin Li,
- Jing Deng,
- Qin-Lu Lin,
- Liang Ma,
- Shan-Shan Feng,
- Xiao-Qi Chen,
- Xiang-Min Zheng,
- Ya-Fu Zhou,
- Yong-Jun Hu,
- Hua-Qun Yin,
- Lin-Lin Tian,
- Li-Peng Gu,
- Zhong-Wei Lv,
- Fei Yu,
- Wen Li,
- Yu-Shui Ma,
- Fu Da
Affiliations
- Yi Shi
- National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China; Cancer Institute, Nantong Tumor Hospital, Nantong 226631, China; College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, China
- Dan-Dan Zhang
- Department of Pathology, Shihezi University School of Medicine, Shihezi 832002, Xinjiang, China; Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Ji-Bin Liu
- Cancer Institute, Nantong Tumor Hospital, Nantong 226631, China
- Xiao-Li Yang
- Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Rui Xin
- Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Cheng-You Jia
- Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Hui-Min Wang
- Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Gai-Xia Lu
- Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Pei-Yao Wang
- Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Yu Liu
- National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China; College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, China
- Zi-Jin Li
- National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China
- Jing Deng
- National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China
- Qin-Lu Lin
- National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China
- Liang Ma
- College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, China
- Shan-Shan Feng
- College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, China
- Xiao-Qi Chen
- National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China
- Xiang-Min Zheng
- College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, China
- Ya-Fu Zhou
- Department of Cardiology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan, China
- Yong-Jun Hu
- Department of Cardiology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan, China
- Hua-Qun Yin
- School of Resource Processing and Bioengineering, Central South University, Changsha 410083, Hunan, China
- Lin-Lin Tian
- Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Li-Peng Gu
- Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Zhong-Wei Lv
- Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Fei Yu
- Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Wen Li
- National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China; College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, China; Corresponding author: Wen Li, PhD, National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, 498 South Shaoshan Road, Changsha 410004, Hunan, China.
- Yu-Shui Ma
- Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China; Department of Pancreatic and Hepatobiliary Surgery, Cancer Hospital, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China; Corresponding author: Yu-Shui Ma, PhD, Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 36 Yunxin Road, Shanghai 200072, China.
- Fu Da
- National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China; Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China; Corresponding author: Da Fu, PhD, Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 36 Yunxin Road, Shanghai 200072, China.
- Journal volume & issue
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Vol. 23
pp. 702 – 718
Abstract
Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors that are harmful to human health. Increasing evidence has underscored the critical role of the competitive endogenous RNA (ceRNA) regulatory networks among various human cancers. However, the complexity and behavior characteristics of the ceRNA network in HCC were still unclear. In this study, we aimed to clarify a phosphatase and tensin homolog (PTEN)-related ceRNA regulatory network and identify potential prognostic markers associated with HCC. The expression profiles of three RNAs (long non-coding RNAs [lncRNAs], microRNAs [miRNAs], and mRNAs) were extracted from The Cancer Genome Atlas (TCGA) database. The DLEU2L-hsa-miR-100-5p/ hsa-miR-99a-5p-TAOK1 ceRNA network related to the prognosis of HCC was obtained by performing bioinformatics analysis. Importantly, we identified the DLEU2L/TAOK1 axis in the ceRNA by using correlation analysis, and it appeared to become a clinical prognostic model by Cox regression analysis. Furthermore, methylation analyses suggested that the abnormal upregulation of the DLEU2L/TAOK1 axis likely resulted from hypomethylation, and immune infiltration analysis showed that the DLEU2L/TAOK1 axis may have an impact on the changes in the tumor immune microenvironment and the development of HCC. In summary, the current study constructing a ceRNA-based DLEU2L/TAOK1 axis might be a novel important prognostic factor associated with the diagnosis and prognosis of HCC.
