Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch

Radhika Malik; Robert E. Johnson; Louise Prakash; Satya Prakash; Iban Ubarretxena-Belandia; Aneel K. Aggarwal

doi:10.1038/s41467-022-28644-7

Nature Communications (Feb 2022)

Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch

Radhika Malik,
Robert E. Johnson,
Louise Prakash,
Satya Prakash,
Iban Ubarretxena-Belandia,
Aneel K. Aggarwal

Affiliations

Radhika Malik: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York
Robert E. Johnson: Department of Biochemistry and Molecular Biology, 301 University Blvd. University of Texas Medical Branch
Louise Prakash: Department of Biochemistry and Molecular Biology, 301 University Blvd. University of Texas Medical Branch
Satya Prakash: Department of Biochemistry and Molecular Biology, 301 University Blvd. University of Texas Medical Branch
Iban Ubarretxena-Belandia: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York
Aneel K. Aggarwal: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York

DOI: https://doi.org/10.1038/s41467-022-28644-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 6

Abstract

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The structure of mismatched DNA-Polζ ternary complex provides a basis for understanding what makes Polζ adept at extending DNA synthesis past mismatched base pairs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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