Targeting tumor vulnerabilities associated with loss of heterozygosity

Abstract

We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type.

Keywords

• loh
• nat2
• colorectal cancer