Nature Communications (Feb 2023)
HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC
- Massimiliano Bissa,
- Sohyoung Kim,
- Veronica Galli,
- Slim Fourati,
- Sarkis Sarkis,
- Anush Arakelyan,
- Isabela Silva de Castro,
- Mohammad Arif Rahman,
- Saori Fujiwara,
- Monica Vaccari,
- Jeffrey A. Tomalka,
- James D. Stamos,
- Luca Schifanella,
- Giacomo Gorini,
- Ramona Moles,
- Anna Gutowska,
- Guido Ferrari,
- Alexei Lobanov,
- David C. Montefiori,
- George W. Nelson,
- Margaret C. Cam,
- Marita Chakhtoura,
- Elias K. Haddad,
- Melvin N. Doster,
- Katherine McKinnon,
- Sophia Brown,
- David J. Venzon,
- Hyoyoung Choo-Wosoba,
- Matthew W. Breed,
- Kristin E. Killoran,
- Joshua Kramer,
- Leonid Margolis,
- Rafick P. Sekaly,
- Gordon L. Hager,
- Genoveffa Franchini
Affiliations
- Massimiliano Bissa
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Sohyoung Kim
- Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health
- Veronica Galli
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Slim Fourati
- Department of Pathology, Case Western Reserve University
- Sarkis Sarkis
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Anush Arakelyan
- Section on Intercellular Interactions, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health
- Isabela Silva de Castro
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Mohammad Arif Rahman
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Saori Fujiwara
- Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health
- Monica Vaccari
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Jeffrey A. Tomalka
- Department of Pathology, Case Western Reserve University
- James D. Stamos
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Luca Schifanella
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Giacomo Gorini
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Ramona Moles
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Anna Gutowska
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Guido Ferrari
- Division of Surgical Sciences, Duke University School of Medicine
- Alexei Lobanov
- Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute
- David C. Montefiori
- Division of Surgical Sciences, Duke University School of Medicine
- George W. Nelson
- Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute
- Margaret C. Cam
- Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute
- Marita Chakhtoura
- Department of Medicine, Drexel University College of Medicine
- Elias K. Haddad
- Department of Medicine, Drexel University College of Medicine
- Melvin N. Doster
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- Katherine McKinnon
- Vaccine Branch Flow Cytometry Core, National Cancer Institute
- Sophia Brown
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- David J. Venzon
- Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute
- Hyoyoung Choo-Wosoba
- Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute
- Matthew W. Breed
- Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory
- Kristin E. Killoran
- Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory
- Joshua Kramer
- Laboratory Animal Sciences Program, Leidos Biomedical Research Inc., Frederick National Laboratory
- Leonid Margolis
- Section on Intercellular Interactions, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health
- Rafick P. Sekaly
- Department of Pathology, Case Western Reserve University
- Gordon L. Hager
- Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health
- Genoveffa Franchini
- Animal Models and Retroviral Vaccines Section, National Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-023-36109-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
HIV vaccine development can be aided by knowledge of correlates of protection. Here the authors identify engagement and reprogramming of tolerogenic CD14+ myeloid cells mediating a spatiotemporal balance of pro- and anti-inflammatory responses, as correlates of efficacy in female macaques vaccinated with the DNA/ALVAC/gp120/Alum platform.
