Nature Communications (Aug 2017)
Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations
- Sarah Kim-Hellmuth,
- Matthias Bechheim,
- Benno Pütz,
- Pejman Mohammadi,
- Yohann Nédélec,
- Nicholas Giangreco,
- Jessica Becker,
- Vera Kaiser,
- Nadine Fricker,
- Esther Beier,
- Peter Boor,
- Stephane E. Castel,
- Markus M. Nöthen,
- Luis B. Barreiro,
- Joseph K. Pickrell,
- Bertram Müller-Myhsok,
- Tuuli Lappalainen,
- Johannes Schumacher,
- Veit Hornung
Affiliations
- Sarah Kim-Hellmuth
- New York Genome Center
- Matthias Bechheim
- Institute of Molecular Medicine, University of Bonn
- Benno Pütz
- Statistical Genetics, Max Planck Institute of Psychiatry
- Pejman Mohammadi
- New York Genome Center
- Yohann Nédélec
- Department of Genetics, CHU Sainte-Justine Research Center
- Nicholas Giangreco
- Department of Systems Biology, Columbia University
- Jessica Becker
- Institute of Human Genetics, University of Bonn
- Vera Kaiser
- Institute of Molecular Medicine, University of Bonn
- Nadine Fricker
- Institute of Human Genetics, University of Bonn
- Esther Beier
- Institute of Molecular Medicine, University of Bonn
- Peter Boor
- Institute of Pathology and Department of Nephrology, University Clinic of RWTH Aachen
- Stephane E. Castel
- New York Genome Center
- Markus M. Nöthen
- Institute of Human Genetics, University of Bonn
- Luis B. Barreiro
- Department of Genetics, CHU Sainte-Justine Research Center
- Joseph K. Pickrell
- New York Genome Center
- Bertram Müller-Myhsok
- Statistical Genetics, Max Planck Institute of Psychiatry
- Tuuli Lappalainen
- New York Genome Center
- Johannes Schumacher
- Institute of Human Genetics, University of Bonn
- Veit Hornung
- Institute of Molecular Medicine, University of Bonn
- DOI
- https://doi.org/10.1038/s41467-017-00366-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Insight into the genetic influence on the immune response is important for the understanding of interindividual variability in human pathologies. Here, the authors generate transcriptome data from human blood monocytes stimulated with various immune stimuli and provide a time-resolved response eQTL map.
