SYNERGY IN MIXED RIBAVERIN-INTERFERON AQUEOS SOLUTIONS

Abstract

Spectrophotometric method of ribavirin determination in aqueous solutions was improved. Feasibility of ribavirin determination in the presence of protein was confirmed. Colloid-chemistry behavior of ribavirin, interferon and their mixture were investigated. We found that these substances are surface active. The synergistic effect was revealed in ribavirin-interferon mixture in aqueous phase. Particular aspects of ribavirin and interferon adsorption from aqueous phase were specified and characteristics of adsorption layers were determined. We found the influence of ribavervirin on isoelectric point and association parameters of interferon macromolecules.

Keywords

• uv spectroscopy
• ribavirin
• interferon
• intermolecular complexes
• adsorption interactions