Targeting endosomal pH for cancer chemotherapy

Abstract

Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).

Keywords

• nhe6
• solute carrier family 9 member a6 (slc9a6)
• chemoresistance
• drug partitioning
• ph-regulation
• endosomes