Advances in multi-omics research on viral hepatitis

Ze Xiang; Jiayuan Li; Di Lu; Di Lu; Di Lu; Di Lu; Xuyong Wei; Xuyong Wei; Xuyong Wei; Xuyong Wei; Xiao Xu; Xiao Xu; Xiao Xu; Xiao Xu

doi:10.3389/fmicb.2022.987324

Frontiers in Microbiology (Sep 2022)

Advances in multi-omics research on viral hepatitis

Ze Xiang,
Jiayuan Li,
Di Lu,
Di Lu,
Di Lu,
Di Lu,
Xuyong Wei,
Xuyong Wei,
Xuyong Wei,
Xuyong Wei,
Xiao Xu,
Xiao Xu,
Xiao Xu,
Xiao Xu

Affiliations

Ze Xiang: Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Jiayuan Li: Zhejiang University School of Medicine, Hangzhou, China
Di Lu: Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Di Lu: Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China
Di Lu: NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China
Di Lu: Institute of Organ Transplantation, Zhejiang University, Hangzhou, China
Xuyong Wei: Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Xuyong Wei: Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China
Xuyong Wei: NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China
Xuyong Wei: Institute of Organ Transplantation, Zhejiang University, Hangzhou, China
Xiao Xu: Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Xiao Xu: Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China
Xiao Xu: NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, China
Xiao Xu: Institute of Organ Transplantation, Zhejiang University, Hangzhou, China

DOI: https://doi.org/10.3389/fmicb.2022.987324
Journal volume & issue: Vol. 13

Abstract

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Viral hepatitis is a major global public health problem that affects hundreds of millions of people and is associated with significant morbidity and mortality. Five biologically unrelated hepatotropic viruses account for the majority of the global burden of viral hepatitis, including hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). Omics is defined as the comprehensive study of the functions, relationships and roles of various types of molecules in biological cells. The multi-omics analysis has been proposed and considered key to advancing clinical precision medicine, mainly including genomics, transcriptomics and proteomics, metabolomics. Overall, the applications of multi-omics can show the origin of hepatitis viruses, explore the diagnostic and prognostics biomarkers and screen out the therapeutic targets for viral hepatitis and related diseases. To better understand the pathogenesis of viral hepatitis and related diseases, comprehensive multi-omics analysis has been widely carried out. This review mainly summarizes the applications of multi-omics in different types of viral hepatitis and related diseases, aiming to provide new insight into these diseases.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

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