Frontiers in Immunology (Jul 2024)

Anti-inflammatory mechanism of Apolipoprotein A-I

  • Xia Tao,
  • Ran Tao,
  • Kaiyang Wang,
  • Lidong Wu

DOI
https://doi.org/10.3389/fimmu.2024.1417270
Journal volume & issue
Vol. 15

Abstract

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Apolipoprotein A-I(ApoA-I) is a member of blood apolipoproteins, it is the main component of High density lipoprotein(HDL). ApoA-I undergoes a series of complex processes from its generation to its composition as spherical HDL. It not only has a cholesterol reversal transport function, but also has a function in modulating the inflammatory response. ApoA-I exerts its anti-inflammatory effects mainly by regulating the functions of immune cells, such as monocytes/macrophages, dendritic cells, neutrophils, and T lymphocytes. It also modulates the function of vascular endothelial cells and adipocytes. Additionally, ApoA-I directly exerts anti-inflammatory effects against pathogenic microorganisms or their products. Intensive research on ApoA-I will hopefully lead to better diagnosis and treatment of inflammatory diseases.

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