Nature Communications (Jun 2022)

RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition

  • Lishan Fang,
  • Dane Ford-Roshon,
  • Max Russo,
  • Casey O’Brien,
  • Xiaozhe Xiong,
  • Carino Gurjao,
  • Maximilien Grandclaudon,
  • Srivatsan Raghavan,
  • Steven M. Corsello,
  • Steven A. Carr,
  • Namrata D. Udeshi,
  • James Berstler,
  • Ewa Sicinska,
  • Kimmie Ng,
  • Marios Giannakis

DOI
https://doi.org/10.1038/s41467-022-30794-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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The RNF43 G659fs mutation occurs frequently in colorectal cancer, but its function remains poorly understood. In this study, the authors show that RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.