PERSISTENT INFECTION IN FREQUENT AND PROLONGED ILL CHILDREN, POSSIBILITIES OF ETIOPATHOGENETIC THERAPY

Abstract

We present the results of the etiologic diagnosis and therapy of 243 frequent and prolonged ill children aged from 1 to 17 years. Microbiological, serological and molecular biological methods for the determination of bacterial agents, respiratory chlamydia and mycoplasma, Epstein-Barr virus, human herpes virus type 6 and cytomegalovirus were used. The dominant role of the active persistence of herpesviruses was shown (87%); bacterial pathogens were identified rarely, mainly in association with herpesvirus. 96 patients received a medication of recombinant interferon D-2 (VIFERON) and then endogenic interferon inductor, 57 patients - recombinant interferon D-2 (VIFERON) in conjunction with antibiotic therapy and then bacterial lysates. Treatment of children depending on the diagnosed infections allowed to achieve stable normalization of state in 78% of cases.

Keywords

• frequent and prolonged ill children
• persistent infection
• differentiated therapy