Modern pharmacological models of Alzheimer’s disease

Abstract

In vivo experimental models of Alzheimers disease are powerfultools for studying the mechanisms of pathogenesis and thesearch for new therapeutic agents. Pharmacological models,based on the injection of neurotoxins (beta-amyloid fragments,cholinotoxins, ibotenic acid) into the brain allow simulation thecognitive impairment typical for Alzheimers disease, and yieldevaluation the impact of drugs on various indicators (biochemical,genetic, electrophysiological). The most validity was showedfor the in vivo model of neurotoxic beta-amyloid fragmentsinjection into basal forebrain nuclei.

Keywords

• alzheimer’s disease
• experimental models
• neurotoxic beta-amyloid fragments