Electrodecoration and Characterization of Superparamagnetic Iron Oxide Nanoparticles with Bioactive Synergistic Nanocopper: Magnetic Hyperthermia-Induced Ionic Release for Anti-Biofilm Action
Verdiana Marchianò,
Maria Salvador,
Amanda Moyano,
Gemma Gutiérrez,
María Matos,
Susana Yáñez-Vilar,
Yolanda Piñeiro,
José Rivas,
José C. Martínez-García,
Davide Peddis,
Maria C. Blanco-López,
Montserrat Rivas,
Nicoletta Ditaranto,
Nicola Cioffi
Affiliations
Verdiana Marchianò
Department of Physical and Analytical Chemistry, University of Oviedo, 33006 Oviedo, Spain
Maria Salvador
Department of Physics and IUTA, University of Oviedo, 33204 Gijon, Spain
Amanda Moyano
Department of Physical and Analytical Chemistry, University of Oviedo, 33006 Oviedo, Spain
Gemma Gutiérrez
Department of Chemical Engineering, University of Oviedo, 33006 Oviedo, Spain
María Matos
Department of Chemical Engineering, University of Oviedo, 33006 Oviedo, Spain
Susana Yáñez-Vilar
Department of Applied Physics, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Yolanda Piñeiro
Department of Applied Physics, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
José Rivas
Department of Applied Physics, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
José C. Martínez-García
Department of Physics and IUTA, University of Oviedo, 33204 Gijon, Spain
Davide Peddis
Istituto di Struttura della Materia—Consiglio Nazionale delle Ricerche (CNR), Monterotondo Scalo (RM), 00016 Rome, Italy
Maria C. Blanco-López
Department of Physical and Analytical Chemistry, University of Oviedo, 33006 Oviedo, Spain
Montserrat Rivas
Department of Physics and IUTA, University of Oviedo, 33204 Gijon, Spain
Nicoletta Ditaranto
Dipartimento di Chimica and CSGI—Bari Unit, Università degli Studi di Bari Aldo Moro, 70125 Bari, Italy
Nicola Cioffi
Dipartimento di Chimica and CSGI—Bari Unit, Università degli Studi di Bari Aldo Moro, 70125 Bari, Italy
The urgency for the availability of new antibacterial/disinfectant agents has become a worldwide priority. At the same time, along with the extensive use of other metal nanoparticles (NPs), the investigation of magnetic NPs (MNPs) in antibacterial studies has turned out to be an increasingly attractive research field. In this context, we present the preparation and characterization of superparamagnetic iron oxide NPs, electrodecorated with antimicrobial copper NPs, able to modulate the release of bioactive species not only by the NP’s stabilizer, but also through the application of a suitable magnetic field. Antimicrobial synergistic CuNPs stabilized by benzalkonium chloride have been used in the current study. We demonstrate the successful preparation of Cu@Fe3O4 MNPs composites through morphological and spectroscopic results. Additionally, an extensive magnetic characterization is reported, along with hyperthermia-induced copper ionic release. On the basis of our results, we propose a new generation of antimicrobial magnetic nanomaterials, whose bioactivity can be also tuned by the application of a magnetic field.
