PLoS ONE (Jan 2012)

Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines.

  • Karobi Moitra,
  • Kate Im,
  • Katy Limpert,
  • Alexander Borsa,
  • Julie Sawitzke,
  • Rob Robey,
  • Naoya Yuhki,
  • Ram Savan,
  • Da Wei Huang,
  • Richard A Lempicki,
  • Susan Bates,
  • Michael Dean

DOI
https://doi.org/10.1371/journal.pone.0045268
Journal volume & issue
Vol. 7, no. 9
p. e45268

Abstract

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In order to develop targeted strategies for combating drug resistance it is essential to understand it's basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.