Synthesis of new dental monomers based on glycidyl methacrylate and their evaluation of cytotoxic and antibacterial activity

Abstract

In this study, glycidyl methacrylate (GMA)-ciprofloxacin and GMA-ampicillin were successfully synthesized as antibacterial dental monomers. The antibacterial activity of resin composites containing 0–5 wt% GMA-ciprofloxacin and GMA-ampicillin was evaluated by using direct contact tests (DCTs) on the cured resins against Streptococcus mutans. After 72 h, the 5 wt% GMA-ciprofloxacin monomer with resin composite showed the highest lethality against Streptococcus mutans. The cytotoxic activity of the synthesized monomers in the concentration range of 5–100 μL mL−1 was investigated against human dental pulp stem cells (DPSCs), and the physical properties of the prepared monomers, such as water sorption, were subsequently assessed. The structure and morphology of the synthesized monomers were characterized using nuclear magnetic resonance (NMR) spectra and field-emission scanning electron microscopy (FE-SEM) techniques. The results revealed that the GMA-ciprofloxacin and GMA-ampicillin monomers were biocompatible at low dosage. The goal of this study was to synthesize new antibacterial monomers and examine their antibacterial properties and cytotoxic activity in dental resin composites.

Keywords

• Antibacterial monomers
• Cytotoxic and antibacterial activity
• Streptococcus mutans
• Dental pulp stem cells