Schizophrenia (Apr 2025)
The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program
- Michael P. Harms,
- Kang-Ik K. Cho,
- Alan Anticevic,
- Nicolas R. Bolo,
- Sylvain Bouix,
- Dylan Campbell,
- Tyrone D. Cannon,
- Guillermo Cecchi,
- Mathias Goncalves,
- Anastasia Haidar,
- Dylan E. Hughes,
- Igor Izyurov,
- Omar John,
- Tina Kapur,
- Nicholas Kim,
- Elana Kotler,
- Marek Kubicki,
- Joshua M. Kuperman,
- Kristen Laulette,
- Ulrich Lindberg,
- Christopher Markiewicz,
- Lipeng Ning,
- Russell A. Poldrack,
- Yogesh Rathi,
- Paul A. Romo,
- Zailyn Tamayo,
- Cassandra Wannan,
- Alana Wickham,
- Walid Yassin,
- Juan Helen Zhou,
- Jean Addington,
- Luis Alameda,
- Celso Arango,
- Nicholas J. K. Breitborde,
- Matthew R. Broome,
- Kristin S. Cadenhead,
- Monica E. Calkins,
- Eric Yu Hai Chen,
- Jimmy Choi,
- Philippe Conus,
- Cheryl M. Corcoran,
- Barbara A. Cornblatt,
- Covadonga M. Diaz-Caneja,
- Lauren M. Ellman,
- Paolo Fusar-Poli,
- Pablo A. Gaspar,
- Carla Gerber,
- Louise Birkedal Glenthøj,
- Leslie E. Horton,
- Christy Lai Ming Hui,
- Joseph Kambeitz,
- Lana Kambeitz-Ilankovic,
- Matcheri S. Keshavan,
- Sung-Wan Kim,
- Nikolaos Koutsouleris,
- Jun Soo Kwon,
- Kerstin Langbein,
- Daniel Mamah,
- Daniel H. Mathalon,
- Vijay A. Mittal,
- Merete Nordentoft,
- Godfrey D. Pearlson,
- Jesus Perez,
- Diana O. Perkins,
- Albert R. Powers,
- Jack Rogers,
- Fred W. Sabb,
- Jason Schiffman,
- Jai L. Shah,
- Steven M. Silverstein,
- Stefan Smesny,
- William S. Stone,
- Gregory P. Strauss,
- Judy L. Thompson,
- Rachel Upthegrove,
- Swapna K. Verma,
- Jijun Wang,
- Daniel H. Wolf,
- Rene S. Kahn,
- John M. Kane,
- Patrick D. McGorry,
- Barnaby Nelson,
- Scott W. Woods,
- Martha E. Shenton,
- Stephen J. Wood,
- Carrie E. Bearden,
- Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ),
- Ofer Pasternak
Affiliations
- Michael P. Harms
- Department of Psychiatry, Washington University School of Medicine
- Kang-Ik K. Cho
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Alan Anticevic
- Department of Psychiatry, Yale University School of Medicine
- Nicolas R. Bolo
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School
- Sylvain Bouix
- Department of Software Engineering and Information Technology, École de technologie supérieure
- Dylan Campbell
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Tyrone D. Cannon
- Department of Psychiatry, Yale University School of Medicine
- Guillermo Cecchi
- T.J. Watson Research Laboratory, IBM Research
- Mathias Goncalves
- Department of Psychology, Stanford University
- Anastasia Haidar
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Dylan E. Hughes
- Department of Psychology, University of California
- Igor Izyurov
- Department of Psychiatry and Psychotherapy, Jena University Hospital
- Omar John
- Massachusetts General Hospital, Harvard Medical School
- Tina Kapur
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Nicholas Kim
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Elana Kotler
- Massachusetts General Hospital, Harvard Medical School
- Marek Kubicki
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Joshua M. Kuperman
- Department of Radiology, University of California
- Kristen Laulette
- Department of Psychology, University of California
- Ulrich Lindberg
- Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet
- Christopher Markiewicz
- Department of Psychology, Stanford University
- Lipeng Ning
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Russell A. Poldrack
- Department of Psychology, Stanford University
- Yogesh Rathi
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Paul A. Romo
- Seaman Family MR Research Centre
- Zailyn Tamayo
- Department of Psychiatry, Yale University School of Medicine
- Cassandra Wannan
- Orygen
- Alana Wickham
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Walid Yassin
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School
- Juan Helen Zhou
- Centre for Sleep and Cognition and Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore
- Jean Addington
- Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary
- Luis Alameda
- General Psychiatry Service, Treatment and Early Intervention in Psychosis Program, Lausanne University Hospital and University of Lausanne
- Celso Arango
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense
- Nicholas J. K. Breitborde
- Department of Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center
- Matthew R. Broome
- Institute for Mental Health, School of Psychology, University of Birmingham
- Kristin S. Cadenhead
- Department of Psychiatry, University of California
- Monica E. Calkins
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Eric Yu Hai Chen
- Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong
- Jimmy Choi
- Olin Neuropsychiatry Research Center, Hartford HealthCare Behavioral Health Network
- Philippe Conus
- General Psychiatry Service, Treatment and Early Intervention in Psychosis Program, Lausanne University Hospital and University of Lausanne
- Cheryl M. Corcoran
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Barbara A. Cornblatt
- Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
- Covadonga M. Diaz-Caneja
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense
- Lauren M. Ellman
- Department of Psychology & Neuroscience, Temple University
- Paolo Fusar-Poli
- Department of Psychosis Studies, King’s College London
- Pablo A. Gaspar
- Department of Psychiatry, University of Chile
- Carla Gerber
- Prevention Science Institute, University of Oregon
- Louise Birkedal Glenthøj
- Copenhagen Research Centre for Mental Health, University of Copenhagen
- Leslie E. Horton
- Department of Psychiatry, University of Pittsburgh School of Medicine
- Christy Lai Ming Hui
- Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong
- Joseph Kambeitz
- Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne
- Lana Kambeitz-Ilankovic
- Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne
- Matcheri S. Keshavan
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School
- Sung-Wan Kim
- Department of Psychiatry, Chonnam National University Medical School
- Nikolaos Koutsouleris
- Department of Psychosis Studies, King’s College London
- Jun Soo Kwon
- Department of Psychiatry, Seoul National University College of Medicine
- Kerstin Langbein
- Department of Psychiatry and Psychotherapy, Jena University Hospital
- Daniel Mamah
- Department of Psychiatry, Washington University School of Medicine
- Daniel H. Mathalon
- Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California
- Vijay A. Mittal
- Department of Psychology, Northwestern University
- Merete Nordentoft
- Copenhagen Research Centre for Mental Health, University of Copenhagen
- Godfrey D. Pearlson
- Department of Psychiatry, Yale University School of Medicine
- Jesus Perez
- Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust
- Diana O. Perkins
- Department of Psychiatry, University of North Carolina at Chapel Hill
- Albert R. Powers
- Department of Psychiatry, Yale University School of Medicine
- Jack Rogers
- Institute for Mental Health, School of Psychology, University of Birmingham
- Fred W. Sabb
- Prevention Science Institute, University of Oregon
- Jason Schiffman
- Department of Psychological Science, University of California
- Jai L. Shah
- Douglas Research Centre, McGill University
- Steven M. Silverstein
- Department of Psychiatry, University of Rochester Medical Center
- Stefan Smesny
- Department of Psychiatry and Psychotherapy, Jena University Hospital
- William S. Stone
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School
- Gregory P. Strauss
- Department of Psychology, University of Georgia
- Judy L. Thompson
- Department of Psychiatry, University of Rochester Medical Center
- Rachel Upthegrove
- Department of Psychology, Ohio State University
- Swapna K. Verma
- Institute of Mental Health
- Jijun Wang
- Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine
- Daniel H. Wolf
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Rene S. Kahn
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- John M. Kane
- Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
- Patrick D. McGorry
- Orygen
- Barnaby Nelson
- Orygen
- Scott W. Woods
- Department of Psychiatry, Yale University School of Medicine
- Martha E. Shenton
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Stephen J. Wood
- Orygen
- Carrie E. Bearden
- Department of Psychology, University of California
- Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
- Ofer Pasternak
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41537-025-00581-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Abstract Neuroimaging with MRI has been a frequent component of studies of individuals at clinical high risk (CHR) for developing psychosis, with goals of understanding potential brain regions and systems impacted in the CHR state and identifying prognostic or predictive biomarkers that can enhance our ability to forecast clinical outcomes. To date, most studies involving MRI in CHR are likely not sufficiently powered to generate robust and generalizable neuroimaging results. Here, we describe the prospective, advanced, and modern neuroimaging protocol that was implemented in a complex multi-site, multi-vendor environment, as part of the large-scale Accelerating Medicines Partnership® Schizophrenia Program (AMP® SCZ), including the rationale for various choices. This protocol includes T1- and T2-weighted structural scans, resting-state fMRI, and diffusion-weighted imaging collected at two time points, approximately 2 months apart. We also present preliminary variance component analyses of several measures, such as signal- and contrast-to-noise ratio (SNR/CNR) and spatial smoothness, to provide quantitative data on the relative percentages of participant, site, and platform (i.e., scanner model) variance. Site-related variance is generally small (typically 55%) due to differences in the diffusion imaging hardware capabilities of the different scanners. Also, spatial smoothness generally has a large platform-related variance due to inherent, difficult to control, differences between vendors in their acquisitions and reconstructions. These results illustrate some of the factors that will need to be considered in analyses of the AMP SCZ neuroimaging data, which will be the largest CHR cohort to date. Watch Dr. Harms discuss this article at https://vimeo.com/1059777228?share=copy#t=0 .
