Nature Communications (Aug 2022)
Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice
- Steven Schepanski,
- Mattia Chini,
- Veronika Sternemann,
- Christopher Urbschat,
- Kristin Thiele,
- Ting Sun,
- Yu Zhao,
- Mareike Poburski,
- Anna Woestemeier,
- Marie-Theres Thieme,
- Dimitra E. Zazara,
- Malik Alawi,
- Nicole Fischer,
- Joerg Heeren,
- Nikita Vladimirov,
- Andrew Woehler,
- Victor G. Puelles,
- Stefan Bonn,
- Nicola Gagliani,
- Ileana L. Hanganu-Opatz,
- Petra C. Arck
Affiliations
- Steven Schepanski
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf
- Mattia Chini
- Institute of Developmental Neurophysiology, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf
- Veronika Sternemann
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf
- Christopher Urbschat
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf
- Kristin Thiele
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf
- Ting Sun
- Institute of Medical Systems Biology, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf
- Yu Zhao
- Institute of Medical Systems Biology, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf
- Mareike Poburski
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf
- Anna Woestemeier
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Marie-Theres Thieme
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf
- Dimitra E. Zazara
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf
- Malik Alawi
- Bioinformatics Service Facility, University Medical Center Hamburg-Eppendorf
- Nicole Fischer
- Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf
- Joerg Heeren
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Nikita Vladimirov
- Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- Andrew Woehler
- Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- Victor G. Puelles
- III Department of Medicine, University Medical Center Hamburg-Eppendorf
- Stefan Bonn
- Institute of Medical Systems Biology, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf
- Nicola Gagliani
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Ileana L. Hanganu-Opatz
- Institute of Developmental Neurophysiology, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf
- Petra C. Arck
- Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-022-32230-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
During pregnancy, maternal cells are transferred to the fetus, where they can reach the developing brain. In this study, the authors demonstrate that these maternal cells play an important role in neurodevelopment.
