Nature Communications (May 2020)
Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
- Ozge Saatci,
- Aysegul Kaymak,
- Umar Raza,
- Pelin G. Ersan,
- Ozge Akbulut,
- Carolyn E. Banister,
- Vitali Sikirzhytski,
- Unal Metin Tokat,
- Gamze Aykut,
- Suhail A. Ansari,
- Hayriye Tatli Dogan,
- Mehmet Dogan,
- Pouria Jandaghi,
- Aynur Isik,
- Fatma Gundogdu,
- Kemal Kosemehmetoglu,
- Omer Dizdar,
- Sercan Aksoy,
- Aytekin Akyol,
- Aysegul Uner,
- Phillip J. Buckhaults,
- Yasser Riazalhosseini,
- Ozgur Sahin
Affiliations
- Ozge Saatci
- Department of Drug Discovery and Biomedical Sciences, University of South Carolina
- Aysegul Kaymak
- Department of Drug Discovery and Biomedical Sciences, University of South Carolina
- Umar Raza
- Faculty of Science, Department of Molecular Biology and Genetics, Bilkent University
- Pelin G. Ersan
- Faculty of Science, Department of Molecular Biology and Genetics, Bilkent University
- Ozge Akbulut
- Faculty of Science, Department of Molecular Biology and Genetics, Bilkent University
- Carolyn E. Banister
- Department of Drug Discovery and Biomedical Sciences, University of South Carolina
- Vitali Sikirzhytski
- Department of Drug Discovery and Biomedical Sciences, University of South Carolina
- Unal Metin Tokat
- Faculty of Science, Department of Molecular Biology and Genetics, Bilkent University
- Gamze Aykut
- Faculty of Science, Department of Molecular Biology and Genetics, Bilkent University
- Suhail A. Ansari
- Faculty of Science, Department of Molecular Biology and Genetics, Bilkent University
- Hayriye Tatli Dogan
- Department of Medical Pathology, Ankara Yildirim Beyazit University
- Mehmet Dogan
- Department of Medical Pathology, Ankara Oncology Education and Research Hospital
- Pouria Jandaghi
- Department of Human Genetics, McGill University
- Aynur Isik
- Hacettepe University Transgenic Animal Technologies Research and Application Center
- Fatma Gundogdu
- Faculty of Medicine, Department of Pathology, Hacettepe University
- Kemal Kosemehmetoglu
- Faculty of Medicine, Department of Pathology, Hacettepe University
- Omer Dizdar
- Department of Medical Oncology, Hacettepe University Cancer Institute
- Sercan Aksoy
- Department of Medical Oncology, Hacettepe University Cancer Institute
- Aytekin Akyol
- Hacettepe University Transgenic Animal Technologies Research and Application Center
- Aysegul Uner
- Faculty of Medicine, Department of Pathology, Hacettepe University
- Phillip J. Buckhaults
- Department of Drug Discovery and Biomedical Sciences, University of South Carolina
- Yasser Riazalhosseini
- Department of Human Genetics, McGill University
- Ozgur Sahin
- Department of Drug Discovery and Biomedical Sciences, University of South Carolina
- DOI
- https://doi.org/10.1038/s41467-020-16199-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
The development of chemoresistance is a major hurdle in triple negative breast cancer (TNBC). Here, the authors show that lysyl oxidase (LOX) is overexpressed in chemoresistant TNBCs, and when inhibited reduces collagen cross-linking, fibronectin fibril assembly, and downstream integrin signalling, overcoming resistance.
