Memorias do Instituto Oswaldo Cruz ()

Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region

  • Rafael Affini Martins,
  • Dandara Cassu-Corsi,
  • Carolina Silva Nodari,
  • Rodrigo Cayô,
  • Larissa Natsumeda,
  • Ana Paula Streling,
  • André Mario Doi,
  • Roberto José Carvalho da Silva,
  • Roberta Alessandra Lima Bocalon,
  • Ana Cristina Gales,
  • Antonio Carlos Campos Pignatari

DOI
https://doi.org/10.1590/0074-02760190079
Journal volume & issue
Vol. 114

Abstract

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A total of 124 Neisseria gonorrhoeae isolates recovered during a 12-year period (2003-2015) from outpatients assisted at Centro de Referência e Treinamento DST/AIDS-CRT of São Paulo city, Brazil, were analysed. The following resistance rates were observed: penicillin-59.6%, ciprofloxacin-15.3%, and azithromycin-6.7%. Although reduced susceptibility to these drugs was observed since 2003, no ceftriaxone-resistant isolates were detected. Ciprofloxacin- and azithromycin non-susceptible isolates were grouped in 11 clusters. Mutations were detected in GyrA and ParC of isolates 124 and 260, and a C2611T substitution on 23S rRNA alleles was also observed in isolate 260. Both isolates belonged to ST1901/ST6210 (MSLT/NG-MAST schemes).

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