GENETIC POLYMORPHISMS OF VEGF AND THEIR INFLUENCE ON THE DEVELOPMENT AND PROGNOSIS OF NON-SMALL CELL LUNG CANCER

Abstract

Lung cancer is the most common malignant tumor in the world associated with high mortality. One of the principle positions in the progression of the neoplasm and spread of the disease belongs to processes related to angiogenesis. Aim of the study: to present effects of the rs699947, rs2010963 and rs3025039 polymorphisms of the VEGF gene responsible for angiogenesis on the extent of tumor progression and survival in patients with non-small cell lung cancer (NSCLC). Material and methods. A total of 172 patients with a diagnosis of NSCLC were included in the study group. All cases were classified according to the TNM / pTNM (7th edition, 2011). The patients were genotyped for the selected polymorphic loci by PCR. Survival analysis of was performed using the life tables in intervals and the Kaplan-Meier method. The results of the study indicate that genetic polymorphism of VEGF influences the course and prognosis of NSCLC. Conclusions: – homozygous genotype -2578CC of the VEGF gene is associated with a greater degree of spread of the tumor; – differences in survival appear after 6 months of the surgery; – survival rate of patients with the VEGF -2578AA genotype during the first years of life exceeds the number of individuals with the VEGF -2578CC genotype; – heterozygous variant of the VEGF -2578CA gene was significantly more common in patients free from disease.

Keywords

• NSCLC - non-small cell lung cancer
• VEGF - endothelial growth factor or vascular endothelium growth factor
• gene
• polymorphism
• angiogenesis
• survival