Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development

Poonam Dhillon; Kelly Ann Mulholland; Hailong Hu; Jihwan Park; Xin Sheng; Amin Abedini; Hongbo Liu; Allison Vassalotti; Junnan Wu; Katalin Susztak

doi:10.1038/s41467-023-36212-w

Nature Communications (Feb 2023)

Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development

Poonam Dhillon,
Kelly Ann Mulholland,
Hailong Hu,
Jihwan Park,
Xin Sheng,
Amin Abedini,
Hongbo Liu,
Allison Vassalotti,
Junnan Wu,
Katalin Susztak

Affiliations

Poonam Dhillon: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Kelly Ann Mulholland: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Hailong Hu: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Jihwan Park: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Xin Sheng: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Amin Abedini: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Hongbo Liu: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Allison Vassalotti: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Junnan Wu: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine
Katalin Susztak: Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine

DOI: https://doi.org/10.1038/s41467-023-36212-w
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 20

Abstract

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The contribution of transposable elements and endogenous retroviruses to renal fibroinflammation is currently unknown. Here, the authors comprehensively profile the expression of transposable elements and endogenous retroviruses (ERVs) in kidneys of patients and mouse disease models and find expression of ERVs in diseased kidneys activate cytosolic nucleotide sensors contributing to cytokine release and renal fibroinflammation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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