Allogeneic Stem Cell Transplantation with CD34+ Cell Selection

Abstract

The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft-versus-host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients. In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice.

Keywords

• Allogeneic transplant
• Graft-versus-host disease
• T cell depletion
• CD34+ cell selection
• Graft-versus-host disease-free and relapse-free survival (GRFS)