Nature Communications (Apr 2022)
Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer
- Jérémy Guillot,
- Chloé Dominici,
- Adrien Lucchesi,
- Huyen Thi Trang Nguyen,
- Angélique Puget,
- Mélanie Hocine,
- Martha M. Rangel-Sosa,
- Milesa Simic,
- Jérémy Nigri,
- Fabienne Guillaumond,
- Martin Bigonnet,
- Nelson Dusetti,
- Jimmy Perrot,
- Jonathan Lopez,
- Anders Etzerodt,
- Toby Lawrence,
- Pierre Pudlo,
- Florence Hubert,
- Jean-Yves Scoazec,
- Serge A. van de Pavert,
- Richard Tomasini,
- Sophie Chauvet,
- Fanny Mann
Affiliations
- Jérémy Guillot
- Aix Marseille Univ, CNRS, IBDM
- Chloé Dominici
- Aix Marseille Univ, CNRS, IBDM
- Adrien Lucchesi
- Aix Marseille Univ, CNRS, IBDM
- Huyen Thi Trang Nguyen
- Aix Marseille Univ, CNRS, IBDM
- Angélique Puget
- Aix Marseille Univ, CNRS, IBDM
- Mélanie Hocine
- Aix Marseille Univ, CNRS, IBDM
- Martha M. Rangel-Sosa
- Aix Marseille Univ, CNRS, IBDM
- Milesa Simic
- Aix Marseille Univ, CNRS, INSERM, CIML
- Jérémy Nigri
- Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM
- Fabienne Guillaumond
- Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM
- Martin Bigonnet
- Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM
- Nelson Dusetti
- Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM
- Jimmy Perrot
- Department of Anatomopathology, Lyon Sud University Hospital, Hospices Civils de Lyon
- Jonathan Lopez
- Department of Biochemistry and Molecular Biology, Lyon Sud University Hospital, Hospices Civils de Lyon
- Anders Etzerodt
- Aix Marseille Univ, CNRS, INSERM, CIML
- Toby Lawrence
- Aix Marseille Univ, CNRS, INSERM, CIML
- Pierre Pudlo
- Aix Marseille Univ, CNRS, Centrale Marseille, I2M
- Florence Hubert
- Aix Marseille Univ, CNRS, Centrale Marseille, I2M
- Jean-Yves Scoazec
- Department of Pathology, Gustave Roussy Cancer Campus
- Serge A. van de Pavert
- Aix Marseille Univ, CNRS, INSERM, CIML
- Richard Tomasini
- Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM
- Sophie Chauvet
- Aix Marseille Univ, CNRS, IBDM
- Fanny Mann
- Aix Marseille Univ, CNRS, IBDM
- DOI
- https://doi.org/10.1038/s41467-022-29659-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
The autonomic nervous systems densely innervate the pancreas, but its contribution to pancreatic ductal adenocarcinoma (PDAC) progression is not fully understood. Here, the authors characterize the pattern of sympathetic innervation by 3D imaging in a murine model of PDAC and show that sympathectomy aggravates cancer progression.
