RISK PREDICTION FOR SUBCLINICAL ATHEROSCLEROTIC LESION OF BRACHIOCEPHALIC ARTERIES IN OBESE WOMEN

Abstract

Aim. To reveal the complex of metabolic risk factors, most significantly related to subclinical atherosclerosis of brachiocephalic arteries (BCA) in obese women.Material and methods. Totally, 89 women included, at the age 25-59 y. o. (50,6±6,6 y. o.) with abdominal obesity — waist circumference >80 cm with no clinical signs of coronary heart disease and atherosclerosis of other localizations. All women underwent duplex DCA scanning with the intima-media thickness assessment (IMT). Also, the main metabolic risk factors were assessed, adipokines of visceral fat tissue, ghrelin. Epicardial fat thickness (tEFT) in millimeters was measured by echo. Veloergometry was performed, to rule out angina and silent myocardial ischemia; cardiovascular risk assessment by SCORE,Framingham, PROCAM.Results. In 32,6% women there were signs of BCA atherosclerosis (IMT more than 1,3-1,5 mm). An equation was invented for logistic regression with the most significant predictors group (ghrelin, CRP, tEFT, leptin), related to subclinical BCA atherosclerosis in obese women, with sensitivity 89,7%.Conclusion. The complex of RF that were collected, might be used in clinical practice to shape a risk group for atherosclerosis in women with obesity, to direct them to prevention orders.

Keywords

• risk factors
• subclinical atherosclerosis
• visceral obesity