This study investigates the load-bearing properties of cross-laminated timber (CLT) under compression perpendicular to the grain. Different series of CLT panels with varying layups, layer thicknesses, and overall depths were tested. Also, the compression perpendicular to the grain properties of CLT plate specimens is compared against clear wood and cubic CLT specimens. The results show a 30% reduction in modulus perpendicular to the grain for cubic samples compared to clear specimens. Increasing the number of layers from three to five leads to a 21% higher modulus, while increasing the overall depth from 105 to 175 mm results (with the same number of layers) in a 17% reduction. The overall depth significantly affects the CLT’s modulus and strength under compression perpendicular to the grain. The study also compares two analytical models for determining the transversal compression factor, kc,90. Although the models showed satisfactory results for thinner CLTs, their accuracy decreased with greater panel depth. These findings enhance the understanding of CLT panels for structural applications.