Frontiers in Pharmacology (Apr 2023)

Cell- and subcellular organelle-targeting nanoparticle-mediated breast cancer therapy

  • Xue Wei,
  • Xue Wei,
  • Ming Yang

DOI
https://doi.org/10.3389/fphar.2023.1180794
Journal volume & issue
Vol. 14

Abstract

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Breast cancer (BC) is the most prevalent malignant tumor, surpassing lung cancer as the most frequent malignancy in women. Drug resistance, metastasis, and immune escape are the major factors affecting patient survival and represent a huge challenge in BC treatment in clinic. The cell- and subcellular organelle-targeting nanoparticles-mediated targeted BC therapy may be an effective modality for immune evasion, metastasis, and drug resistance. Nanocarriers, efficiently delivering small molecules and macromolecules, are used to target subcellular apparatuses with excellent targeting, controlled delivery, and fewer side effects. This study summarizes and critically analyzes the latest organic nanoparticle-mediated subcellular targeted therapeutic based on chemotherapy, gene therapy, immunotherapy, and combination therapy in detail, and discusses the challenges and opportunities of nanoparticle therapy.

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