Programmable mutually exclusive alternative splicing for generating RNA and protein diversity

Melina Mathur; Cameron M. Kim; Sarah A. Munro; Shireen S. Rudina; Eric M. Sawyer; Christina D. Smolke

doi:10.1038/s41467-019-10403-w

Nature Communications (Jun 2019)

Programmable mutually exclusive alternative splicing for generating RNA and protein diversity

Melina Mathur,
Cameron M. Kim,
Sarah A. Munro,
Shireen S. Rudina,
Eric M. Sawyer,
Christina D. Smolke

Affiliations

Melina Mathur: Department of Bioengineering, Stanford University
Cameron M. Kim: Department of Bioengineering, Stanford University
Sarah A. Munro: Department of Bioengineering, Stanford University
Shireen S. Rudina: Department of Bioengineering, Stanford University
Eric M. Sawyer: Department of Bioengineering, Stanford University
Christina D. Smolke: Department of Bioengineering, Stanford University

DOI: https://doi.org/10.1038/s41467-019-10403-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Alternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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