Synthesis, In Vitro Anti-Microbial Analysis and Molecular Docking Study of Aliphatic Hydrazide-Based Benzene Sulphonamide Derivatives as Potent Inhibitors of α-Glucosidase and Urease
Shoaib Khan,
Shahid Iqbal,
Mazloom Shah,
Wajid Rehman,
Rafaqat Hussain,
Liaqat Rasheed,
Hamad Alrbyawi,
Ayed A. Dera,
Mohammed Issa Alahmdi,
Rami Adel Pashameah,
Eman Alzahrani,
Abd-ElAziem Farouk
Affiliations
Shoaib Khan
Department of Chemistry, Hazara University, Mansehra 21120, Pakistan
Shahid Iqbal
Department of Chemistry, School of Natural Sciences (SNS), National University of Science and Technology (NUST), H-12, Islamabad 46000, Pakistan
Mazloom Shah
Department of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad 22010, Pakistan
Wajid Rehman
Department of Chemistry, Hazara University, Mansehra 21120, Pakistan
Rafaqat Hussain
Department of Chemistry, Hazara University, Mansehra 21120, Pakistan
Liaqat Rasheed
Department of Chemistry, Hazara University, Mansehra 21120, Pakistan
Hamad Alrbyawi
Pharmaceutics and Pharmaceutical Technology Department, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia
Ayed A. Dera
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61413, Saudi Arabia
Mohammed Issa Alahmdi
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia
Rami Adel Pashameah
Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah 24230, Saudi Arabia
Eman Alzahrani
Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Abd-ElAziem Farouk
Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
A unique series of sulphonamide derivatives was attempted to be synthesized in this study using a new and effective method. All of the synthesized compounds were verified using several spectroscopic methods, including FTIR, 1H-NMR, 13C-NMR, and HREI-MS, and their binding interactions were studied using molecular docking. The enzymes urease and α-glucosidase were evaluated against each derivative (1–15). When compared to their respective standard drug such as acarbose and thiourea, almost all compounds were shown to have excellent activity. Among the screened series, analogs 5 (IC50 = 3.20 ± 0.40 and 2.10 ± 0.10 µM) and 6 (IC50 = 2.50 ± 0.40 and 5.30 ± 0.20 µM), emerged as potent molecules when compared to the standard drugs acarbose (IC50 = 8.24 ± 0.08 µM) and urease (IC50 = 7.80 ± 0.30). Moreover, an anti-microbial study also demonstrated that analogs 5 and 6 were found with minimum inhibitory concentrations (MICs) in the presence of standard drugs streptomycin and terinafine.
