Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications

Yuling Xu; Chonglu Li; Shuai Lu; Zhizheng Wang; Shuang Liu; Xiujun Yu; Xiaopeng Li; Yao Sun

doi:10.1038/s41467-022-29572-2

Nature Communications (Apr 2022)

Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications

Yuling Xu,
Chonglu Li,
Shuai Lu,
Zhizheng Wang,
Shuang Liu,
Xiujun Yu,
Xiaopeng Li,
Yao Sun

Affiliations

Yuling Xu: Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University
Chonglu Li: Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University
Shuai Lu: Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen
Zhizheng Wang: Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University
Shuang Liu: School of Materials Science and Engineering, Wuhan University of Technology
Xiujun Yu: Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen
Xiaopeng Li: Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen
Yao Sun: Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University

DOI: https://doi.org/10.1038/s41467-022-29572-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Ruthenium (Ru(II)) compounds are of interest as platinum drug replacements but have suffered from suboptimal therapeutic efficiency. Here, the authors design a Ru(II) metallacycle with NIR excitation and emission wavelengths and demonstrate application for deep tumour imaging and chemo-photo therapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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