ATIP/ATIP1 regulates prostate cancer metastasis through mitochondrial dynamic-dependent signaling

Yuan Haokun; Fang Ruiqin; Fu Chi; Wang Shuo; Tong Xiaoqin; Feng Deyi; Wei Xiaoqing; Hu Xirong; Wang Yuan

doi:10.3724/abbs.2024006

Acta Biochimica et Biophysica Sinica (Jan 2024)

ATIP/ATIP1 regulates prostate cancer metastasis through mitochondrial dynamic-dependent signaling

Yuan Haokun,
Fang Ruiqin,
Fu Chi,
Wang Shuo,
Tong Xiaoqin,
Feng Deyi,
Wei Xiaoqing,
Hu Xirong,
Wang Yuan

Affiliations

Yuan Haokun: ["The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People′s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China","The School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China"]
Fang Ruiqin: ["The School of Life Science, University of Electronic Science and Technology of China, Chengdu 610054, China"]
Fu Chi: ["The School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China"]
Wang Shuo: ["The School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China"]
Tong Xiaoqin: ["The School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China"]
Feng Deyi: ["State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361104, China"]
Wei Xiaoqing: ["The School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China"]
Hu Xirong: ["The School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China"]
Wang Yuan: ["The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine, Sichuan Provincial People′s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China","The School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China"]

DOI: https://doi.org/10.3724/abbs.2024006
Journal volume & issue: Vol. 56
pp. 304 – 314

Abstract

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Mitochondria play a fundamental role in cell survival and motility. Abnormalities in mitochondria are associated with carcinogenesis, especially with tumor metastasis. In this study, we explore the biological function of ATIP1, which is a mitochondrial-located isoform of angiotensin II AT2 receptor interacting proteins (ATIPs) in prostate cancer cells. The results showed that ATIP is downregulated in prostate cancer tissues and is negatively correlated with the disease-free survival rate of prostate cancer patients. Silencing of ATIP promotes mitochondrial fission and enhances tumor cell migration and invasion. Reconstitution of ATIP1 in ATIP-deficient cells significantly attenuates mitochondrial trafficking and tumor cell movement. Therefore, ATIP1 is a negative regulator of mitochondrial dynamics and tumor cell motility and is also a potential biomarker for predicting prostate cancer malignancy.

Published in Acta Biochimica et Biophysica Sinica

ISSN: 1672-9145 (Print); 1745-7270 (Online)
Publisher: China Science Publishing & Media Ltd.
Country of publisher: China
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry; Science: Biology (General): Genetics
Website: https://www.sciengine.com/ABBS/home

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