Comparison of bone age in small-for-gestationalage children vs appropriate-for-getational-age children

Paediatrica Indonesiana. 2010;50(2):73-9 DOI 10.14238/pi50.2.2010.73-9


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Journal Title: Paediatrica Indonesiana

ISSN: 0030-9311 (Print); 2338-476X (Online)

Publisher: Indonesian Pediatric Society Publishing House

Society/Institution: Indonesian Pediatric Society

LCC Subject Category: Medicine: Pediatrics

Country of publisher: Indonesia

Language of fulltext: English

Full-text formats available: PDF



Lionardus Edward (Padjadjaran University, Hasan Sadikin General Hospital)
Sjarif Hidajat Effendi (Padjadjaran University, Hasan Sadikin General Hospital)
Djatnika Setiabudi (Padjadjaran University, Hasan Sadikin General Hospital)


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Time From Submission to Publication: 24 weeks


Abstract | Full Text

BackgroundAbout 10-15% small-for-gestational-age children are in higher risk for having linear growth retardation due to growth hormone-insulin like growth factor 1 axis defect (GH-IGF 1) which causes bone age delay.ObjectivesTo compare bone age in 24-36 month old children born small-for-gestational-age (SGA) to that in children born appropriate-for-gestational-age (AGA).MethodsA cross-sectional study was conducted in Hasan Sadikin General Hospital, Bandung, from January to April 2009.Subjects consisted of50 healthy children of 24-36 months old (25 children born at term, SGA, 25 children born at term, AGA). We compared the appropriateness and delay of bone age between the two groups. ResultsMean bone age in the SGA group was 20.8 (SD 7.7) months, and in the AGA group was 25.7 (SD 7.1) months (P=0.022). Mean bone age deficit was -10.5 (6.5) months in the SGA group and -5.5 (SD 5.7) months in the AGA group (P=0.009). The prevalence ratio was 1.77 (95% CI: 1.19–2.62). Bone age delay was found to be higher in children born SGA than that in children of the other group (23 vs 13). On the contrary, appropriate bone age was found more in children born AGA (12 vs 2) (P=0.002).Conclusion Bone age delay in 24-36 months old children born small-for-gestational-age was found to be higher than in those born appropriate-for-gestational-age.