Gelatin nanofibers: Recent insights in synthesis, bio-medical applications and limitations
Hesham R. El-Seedi,
Noha S. Said,
Nermeen Yosri,
Hamada B. Hawash,
Dina M. El-Sherif,
Mohamed Abouzid,
Mohamed M. Abdel-Daim,
Mohammed Yaseen,
Hany Omar,
Qiyang Shou,
Nour F. Attia,
Xiaobo Zou,
Zhiming Guo,
Shaden A.M. Khalifa
Affiliations
Hesham R. El-Seedi
International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China; International Joint Research Laboratory of Intelligent Agriculture and Agri-products Processing, Jiangsu Education Department, Zhenjiang 212013, China; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt; Corresponding author. International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.
Noha S. Said
Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt
Nermeen Yosri
Chemistry Department of Medicinal and Aromatic Plants, Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef 62514, Egypt; School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Hamada B. Hawash
Environmental Division, National Institute of Oceanography and Fisheries, NIOF, Cairo, Egypt
Dina M. El-Sherif
National Institute of Oceanography and Fisheries, NIOF, Cairo, Egypt
Mohamed Abouzid
Department of Physical Pharmacy and Pharmacokinetics, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland
Mohamed M. Abdel-Daim
Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231 Jeddah 21442, Saudi Arabia; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt
Mohammed Yaseen
School of Computing, Engineering & Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK
Hany Omar
Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates
Qiyang Shou
Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China
Nour F. Attia
Gas Analysis and Fire Safety Laboratory, Chemistry Division, National Institute of Standards, 136, Giza 12211, Egypt
Xiaobo Zou
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Zhiming Guo
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Shaden A.M. Khalifa
Psychiatry and Psychology Department, Capio Saint Göran's Hospital, Sankt Göransplan 1, 112 19 Stockholm, Sweden
The use of gelatin and gelatin-blend polymers as environmentally safe polymers to synthesis electrospun nanofibers, has caused a revolution in the biomedical field. The development of efficient nanofibers has played a significant role in drug delivery, and for use in advanced scaffolds in regenerative medicine. Gelatin is an exceptional biopolymer, which is highly versatile, despite variations in the processing technology. The electrospinning process is an efficient technique for the manufacture of gelatin electrospun nanofibers (GNFs), as it is simple, efficient, and cost-effective. GNFs have higher porosity with large surface area and biocompatibility, despite that there are some drawbacks. These drawbacks include rapid degradation, poor mechanical strength, and complete dissolution, which limits the use of gelatin electrospun nanofibers in this form for biomedicine. Thus, these fibers need to be cross-linked, in order to control its solubility. This modification caused an improvement in the biological properties of GNFs, which made them suitable candidates for various biomedical applications, such as wound healing, drug delivery, bone regeneration, tubular scaffolding, skin, nerve, kidney, and cardiac tissue engineering. In this review an outline of electrospinning is shown with critical summary of literature evaluated with respect to the various applications of nanofibers-derived gelatin.
