Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease

• Jennifer O. Nwankwo,
• Jianxun Lei,
• Jian Xu,
• Alicia Rivera,
• Kalpna Gupta,
• Athar H. Chishti

Affiliations

Jennifer O. Nwankwo

Graduate Program in Pharmacology and Experimental Therapeutics, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA

Jianxun Lei

Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN

Jian Xu

Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX

Alicia Rivera

Department of Laboratory Medicine, Boston Children’s Hospital and Department of Pathology, Harvard Medical School, Boston, MA

Kalpna Gupta

Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN

Athar H. Chishti

Graduate Program in Pharmacology and Experimental Therapeutics, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA;Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA