Nature Communications (Mar 2022)
ADARs act as potent regulators of circular transcriptome in cancer
- Haoqing Shen,
- Omer An,
- Xi Ren,
- Yangyang Song,
- Sze Jing Tang,
- Xin-Yu Ke,
- Jian Han,
- Daryl Jin Tai Tay,
- Vanessa Hui En Ng,
- Fernando Bellido Molias,
- Priyankaa Pitcheshwar,
- Ka Wai Leong,
- Ker-Kan Tan,
- Henry Yang,
- Leilei Chen
Affiliations
- Haoqing Shen
- Cancer Science Institute of Singapore, National University of Singapore
- Omer An
- Cancer Science Institute of Singapore, National University of Singapore
- Xi Ren
- Cancer Science Institute of Singapore, National University of Singapore
- Yangyang Song
- Cancer Science Institute of Singapore, National University of Singapore
- Sze Jing Tang
- Cancer Science Institute of Singapore, National University of Singapore
- Xin-Yu Ke
- Cancer Science Institute of Singapore, National University of Singapore
- Jian Han
- Cancer Science Institute of Singapore, National University of Singapore
- Daryl Jin Tai Tay
- Cancer Science Institute of Singapore, National University of Singapore
- Vanessa Hui En Ng
- Cancer Science Institute of Singapore, National University of Singapore
- Fernando Bellido Molias
- Cancer Science Institute of Singapore, National University of Singapore
- Priyankaa Pitcheshwar
- Cancer Science Institute of Singapore, National University of Singapore
- Ka Wai Leong
- Cancer Science Institute of Singapore, National University of Singapore
- Ker-Kan Tan
- Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore
- Henry Yang
- Cancer Science Institute of Singapore, National University of Singapore
- Leilei Chen
- Cancer Science Institute of Singapore, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-022-29138-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
RNA editing and circRNAs are involved in tumorigenesis. Here the authors report that ADARs regulate the circular transcriptome in a bidirectional manner through and beyond their editing function in multiple cancer cells.
