Reply to “Comment on López-Yerena et al. ‘Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats’ <i>Pharmaceutics</i> 2020, <i>12</i>, 134”
Anallely López-Yerena,
Anna Vallverdú-Queralt,
Raf Mols,
Patrick Augustijns,
Rosa M. Lamuela-Raventós,
Elvira Escribano-Ferrer
Affiliations
Anallely López-Yerena
Nutrition, Food Science and Gastronomy Department, XaRTA, Institute of Nutrition and Food Safety (INSA-UB), School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
Anna Vallverdú-Queralt
Nutrition, Food Science and Gastronomy Department, XaRTA, Institute of Nutrition and Food Safety (INSA-UB), School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
Raf Mols
Drug Delivery and Disposition, KU Leuven, 3000 Leuven, Belgium
Patrick Augustijns
Drug Delivery and Disposition, KU Leuven, 3000 Leuven, Belgium
Rosa M. Lamuela-Raventós
Nutrition, Food Science and Gastronomy Department, XaRTA, Institute of Nutrition and Food Safety (INSA-UB), School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
Elvira Escribano-Ferrer
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain
Recently, in February 2020, we published a study exploring the intestinal absorption and metabolism of oleocanthal (OLC) in rats. A single-pass intestinal perfusion technique (SPIP) was used, involving simultaneous sampling from the luminal perfusate and mesenteric blood. Later, comments on our published paper were released, requesting clarification of specific data. In this detailed reply, we hope to have addressed and clarified all the concerns of A. Kaddoumi and K. El Sayed and that the scientific community will benefit from both the study and the comments it has generated.
