Biomedicines (May 2017)

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer

  • Carlota Colomer,
  • Laura Marruecos,
  • Anna Vert,
  • Anna Bigas,
  • Lluis Espinosa

DOI
https://doi.org/10.3390/biomedicines5020026
Journal volume & issue
Vol. 5, no. 2
p. 26

Abstract

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Nuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent years, the study of NF-κB members in NF-κB unrelated pathways provided novel attractive targets for cancer therapy, specifically linked to particular pathologic responses. Here we review specific functions of IκB kinase complexes (IKKs) and IκBs, which have distinctly tumor promoting or suppressing activities in cancer. Understanding how these proteins are regulated in a tumor-related context will provide new opportunities for drug development.

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