Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland

Abstract

We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.

Keywords

• 2019 novel coronavirus disease
• coronavirus disease
• COVID-19
• severe acute respiratory syndrome coronavirus 2
• SARS-CoV-2
• viruses