Nature Communications (Dec 2022)
Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer
- Lichun Ma,
- Sophia Heinrich,
- Limin Wang,
- Friederike L. Keggenhoff,
- Subreen Khatib,
- Marshonna Forgues,
- Michael Kelly,
- Stephen M. Hewitt,
- Areeba Saif,
- Jonathan M. Hernandez,
- Donna Mabry,
- Roman Kloeckner,
- Tim F. Greten,
- Jittiporn Chaisaingmongkol,
- Mathuros Ruchirawat,
- Jens U. Marquardt,
- Xin Wei Wang
Affiliations
- Lichun Ma
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Sophia Heinrich
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Limin Wang
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Friederike L. Keggenhoff
- Department of Medicine I, Lichtenberg Research Group, Johannes Gutenberg University
- Subreen Khatib
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Marshonna Forgues
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Michael Kelly
- Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc.
- Stephen M. Hewitt
- Laboratory of Pathology, Center for Cancer Research, National Cancer Institute
- Areeba Saif
- Surgical Oncology Program, Center for Cancer Research, National Cancer Institute
- Jonathan M. Hernandez
- Surgical Oncology Program, Center for Cancer Research, National Cancer Institute
- Donna Mabry
- Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute
- Roman Kloeckner
- Department of Medicine I, Lichtenberg Research Group, Johannes Gutenberg University
- Tim F. Greten
- Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute
- Jittiporn Chaisaingmongkol
- Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute
- Mathuros Ruchirawat
- Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute
- Jens U. Marquardt
- Department of Medicine I, Lichtenberg Research Group, Johannes Gutenberg University
- Xin Wei Wang
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-022-35291-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Multiregion sequencing is needed to better capture the heterogeneity of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Here, the authors analyse HCC and iCCA tumours with multiregion single-cell RNA-seq, revealing cellular dynamics and communication networks with immune cells.
