Type of Electrical Stimulation Influences Diaphragm Response to Adrenoceptor and Calcium Channel Modulators: the Role of Extracellular and Intracellular Calcium Events

Zoran Todorovic; Radan Stojanovic; Zorica Nešic; Nevena Divac; Nikola Vojvodic; Nataša Cerovac-Cosic; Milica Prostran

Journal of Pharmacological Sciences (Jan 2006)

Type of Electrical Stimulation Influences Diaphragm Response to Adrenoceptor and Calcium Channel Modulators: the Role of Extracellular and Intracellular Calcium Events

Zoran Todorovic,
Radan Stojanovic,
Zorica Nešic,
Nevena Divac,
Nikola Vojvodic,
Nataša Cerovac-Cosic,
Milica Prostran

Affiliations

Zoran Todorovic: Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia and Montenegro
Radan Stojanovic: Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia and Montenegro
Zorica Nešic: Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia and Montenegro
Nevena Divac: Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia and Montenegro
Nikola Vojvodic: Institute of Neurology, School of Medicine, University of Belgrade, Belgrade, Serbia and Montenegro
Nataša Cerovac-Cosic: Clinic for Child Neurology and Psychiatry, Medical Faculty, University of Belgrade, Belgrade, Serbia and Montenegro
Milica Prostran: Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia and Montenegro; Corresponding author. mprostran@doctor.com

Journal volume & issue: Vol. 102, no. 3
pp. 347 – 353

Abstract

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The influence of direct single pulse and subtetanic electrical stimulation (ES) on isolated rat hemidiaphragm response to adrenoceptor antagonists and calcium channel blockers was investigated. Muscle contractility was stimulated by cumulative micromolar noradrenaline. Noradrenaline effects on developed tension (Td) in the presence of various α- and β-adrenoceptor antagonists (e.g., prazosin and ICI 118551) were qualitatively different during different types of ES. Also, intact L-voltage calcium channels were necessary for noradrenaline-induced potentiation of Td during both types of ES, while the balance between ryanodine receptors- and inositol triphosphate (IP3)-related calcium events in the muscle was influenced by the pattern of the ES. Keywords:: adrenoceptor antagonist, calcium channel blocker, electrical stimulation

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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